A study conducted by some students from the Faculty of Pharmacy Gadjah Mada University (UGM) about what substances are stored in the fingerroot, and its benefits for health. They want to find a solution for the treatment of cancer that is currently suffered by many people.
Fingerroot (Boesenbergia pandurata) that is often used as spices for vegetables contain substances Panduratin A and is known to inhibit the growth of cancer cells.
“Panduratin A, which belongs to the class of Kalkon compounds, proved to inhibit the activity of the enzyme Glutathione S-Transferase (GST),” said Aida Fathia one of the students, as reported by the republika.com page.
Aida and her team-mates explore the potential of fingerroot as a chemoprevention agent in inhibiting cancer cell metabolism.
“In vitro and in silico,” she added.
They used breast cancer cells 4T1 as test materials in the study. The result, fingerroot extract can inhibit cancer cell metabolism. Evident from the GST enzymes and levels of ROS in cells that are experiencing a decrease in activity.
In the molecular docking test, the result of Panduratin A compound in the fingerroot will bind to the GST enzyme. That is, the fingerroot has the potential as a chemoprevention agent. It reduces the action of GST enzymes in cancer cells.
This research is expected to be the beginning of further research, said Aida.
“To develop a supplement product that can be consumed as a chemoprevention agent against breast cancer,” she said.